Stocks with high short interest often make explosive short-term moves when they break out. Shorts scramble to cover, leading to big buying stampedes.
EYPT is a recent example of one such stock
If you are looking for high short-interest stocks and have TC2000 you can download this list of around the top 250 stocks by the high short-interest which I compiled this week
https://www.tc2000.com/~AECNUo